Forsythe Protocol & The Role of Lipoic Acid Mineral Complex in Integrative Medicine
Introduction / Background
Currently, Dr. Forsythe at the Forsythe Cancer Center is and has been examining the
adjunctive effects of Poly-MVA in Integrative Oncology for the last 12 years. Its most
active ingredient is a novel organo-mineral compound called Lipoic Acid Mineral
Complex (LAMC), which facilitates charge transfer to provide metabolically-targeted
therapy. From 2004-2006 Dr. James Forsythe studied 225 stage IV cancer patients
(multiple origins). Treatment with Poly-MVA or Poly-MVA + chemotherapy provided a 6-
year Overall Survival rate of 32%, while the average 5-year survival rate is 2.1% in all
stage IV cancers, as reported in the Clinical Journal of Oncology.
Materials and Methods
Dr. Forsythe’s is now utilizing genetic chemo-sensitivity testing, immune therapy, insulin-
potentiated therapy, along with IV Poly-MVA to enhance his results. The patients are
discharged on oral Poly-MVA and targeted treatments, with follow-up every 3 months.
Thus far in his current 6 year study of 1,000 patients having a 70% survival rate.
Summary / Conclusions
In 2009 Poly-MVA completed an IND safety study and is currently being utilized as
integrative support in glioblastoma (Stony Brook University) and multiple myeloma
(Virginia Tech-College of Osteopathic Medicine) IND studies. Dr. Forsythe's ongoing
of Osteopathic Medicine) IND studies. Dr. Forsythe’s ongoing outcome-based study
continues to Demonstrate Poly MVA’s role in the Integrative Oncology arena. By
enhancing aerobic Cellular metabolism, Poly-MVA potentiates therapy, attenuates
side effects and enhances a patient's quality of life.
Lipoic Acid Mineral Complex (LAMC) is the most active ingredient in a dietary
supplement called Poly-MVA. In the LAMC complex, the transition metal palladium is
bound to the anti-oxidant alpha lipoic acid, creating a potent redox polymer that is a fat
and water soluble. in addition to LAMC, this proprietary blend is formulated with
minerals, vitamins and amino acids such as molybdenum, rhodium, ruthenium,
thiamine, riboflavin, cyanocobalamin, acetyl cysteine, and formyl methionine. Redox
polymers are very efficient at accepting and transferring charge (electrons), which is
the basis of cellular metabolism. A unique characteristic of cancer cells is that they have
a disrupted metabolism. Malignant cells favor an anaerobic metabolism (red oval in
figure below) and make physiologic adaptations to a hypoxic environment.
Lipoic Acid Mineral Complex (LAMC)
Role in Energy Metabolism
In contrast, LAMC facilitates aerobic metabolism since thiamine and lipoic acid act as
cofactors in the conversion of pyruvate at Complex I of the mitochondria, which targets
LAMC’s energy to theaerobic cascade (figure above). Our research has focused on
LAMC as a metabolically-targeted therapy.
1. FORSYTHE PROTOCOL / POLY-MVA INVESTIGATION
Physical Exam : tumors in skin, liver, spleen, lymph nodes, etc.
X-Rays: tumors detectable in CXR, bone X-rays, mammograms, etc.
CT Scanning*: tumors detectable in brain, chest, abdomen, pelvis or bones
Ultrasounds: breast GB, liver, ovaries, spleen, etc.
MRIs: brain, neck, sinuses, joints, breasts, muscles, soft tissues, etc.
Pet Scans*: total body scanning
Chemo-sensitivity testing: on whole blood (RGCC, Inc.)
Hormonal balancing testing: saliva or blood
(* Dr. Forsythe discourages the excessive use of CT/PET scanning)
2. FORSYTHE PROTOCOL / POLY-MVA INVESTIGATION
Bladder: NMP-22, BTA
Breast: CEA, CA 27-29, CA 15-3
Colorectal: CEA, CA19-9, 5HIAA (Carcinoids)
Esophagus: CEA, CA 19-9
Gastric: CEA, CA 19-9
Liver: AFP, CEA, CA 19-9
Lung: CEA, CA 19-9
Lymphomas: ESR, LDH, Beta-2 microglobulin, SPE
Myeloma: B2MG, SPE, LDH, ESR
Pancreas: CEA, CA 19-9
Prostate: PSA, Free PSA
Ovary: CA 125
Testes: AFP, HCG
3. THE FORSYTHE IMMUNE PROTOCOL
1. Normal Saline 7. L-Lysine
2. Magnesium Cl 8. Zinc
3. Pyridoxine 9. L-Glutathione
4. Vitamin B-12 10. Folic Acid
5. Vitamin C 11. DMSO
6. B Complex 12. Oral Poly-MVA on non-IV days
4. STANDARD 3-WEEK PROTOCOL
Monday: Forsythe Immune Protocol + Poly-MVA IV
Tuesday: Forsythe IPT Lite + L-Glutathione IV
Wednesday: Super “C” (50 grams) + H2O2 IV
Thursday: Forsythe IPT Lite + L-Glutathione IV
Friday: Forsythe Immune Protocol + Poly-MVA IV
Discharged to home on maintenance: Poly-MVA oral, targeted
Note: Case studies furnished upon request.